[1260533-36-5]    

MFCD28502196

Synonyms : 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl)-1H-pyrazolo[3,4-b]pyridin-1-yl)benzamide; TAS-116

Applications : Pimitespib is an oral bioavailable, ATP-competitive, highly specific Hsp90α/Hsp90β inhibitor (Kis of 34.7 nM and 21.3 nM, respectively) without inhibiting other Hsp90 family proteins such as GRP94. Pimitespib demonstrates less ocular toxicity. Pimitespib has the potential to be a new standard treatment in advanced gastrointestinal stromal tumor (GIST).

References : Ohkubo S. et al.: Mol Cancer Ther., 14(1), 14-22, 2015; Suzuki R. et al.: Leukemia 29(2), 510-4, 2015; Utsugi T.: Jpn. J. Clin. Oncol., 43(10), 945-53, 2013; Honma Y. et al.: Journal of Clinical Oncology 39(15), 11524-11524, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.