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Synonyms : (E)-N-(4-Hydroxy-3-methoxybenzyl)-9-methyldec-7-enamide; E-Homocapsaicin; Homocapsaicin

Applications : Homocapsaicin-I is a Capsaicinoid and an analog of Capsaicin, which is the principal pungent component in hot peppers, including red chilli peppers, and it has a profound antiproliferative effect on prostate cancer cells, inducing the apoptosis of both androgen receptor (AR)-positive (LNCaP) and -negative (PC-3, DU-145) prostate cancer cell lines associated with an increase of p53, p21, and Bax.Capsaicin inhibited NF-kappa activation by preventing its nuclear migration.

References : Kozukue N. et al.: J. Agric. Food Chem. 53, 9172, 2005; Choi S. et al.: J. Agric. Food Chem. 54, 9224, 2006.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.