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SI-3271

DDD107498, >98% (HPLC)

CAS No. : 
[1469439-69-7]    
Synonyms : 6-Fluoro-2-(4-(morpholinomethyl)phenyl)-N-(2-(pyrrolidin-1-yl)ethyl)quinoline-4-carboxamide; DDD 498

Price and Availability
Pack Size Price in USD Quantity Availability Shipping Status
5MGRequest QuoteBack Order Estimated to Ship on 01.20.2025
25MGRequest QuoteBack Order Estimated to Ship on 01.20.2025
100MGRequest QuoteBack Order Estimated to Ship on 01.20.2025

DDD107498 is not in stock, can be available through custom synthesis. The estimated lead-time is 4-6 weeks. The product will be characterized by NMR and MS analysis. Purity (HPLC) is usually >98%. COA, QC data, SDS will be provided along with the product. For information on pricing and availability please contact us at sales@syninnova.com or submit the following Bulk Quote Request. We respond promptly. Thank You!

Chemical Properties
C27H31FN4O2 462.56
Solid Not available
For Laboratory research use only, not for drug, household or other uses.
Applications : DDD107498 is a multiple-stage antimalarial agent that inhibits protein synthesis. DDD107498 demonstrates potential to address a variety of clinical needs, including single-dose treatment, transmission blocking and chemoprotection. DDD107498 was developed from a screening programme against blood-stage malaria parasites; its molecular target has been identified as translation elongation factor 2 (eEF2), which is responsible for the GTP-dependent translocation of the ribosome along messenger RNA, and is essential for protein synthesis. This discovery of eEF2 as a viable antimalarial drug target opens up new possibilities for drug discovery.
References : Fidock D. A. et al.: Nature, 522(7556), 315-320, 2015; Baragana B. et al.: J. Med. Chem., 59(21), 9672-9685, 2016.
Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SI-3271

Product Name : DDD107498

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