[1430741-35-7]    

Synonyms : N-((R)-Cyclopropyl(pyridin-2-yl)methyl)-3-(4-((endo)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl)phenyl)-1H-indazole-5- carboxamide

Applications : CFI-401870 is a orally bioavailable, potent tyrosine threonine kinase (TTK) inhibitor (TTK IC₅₀ < 10 nM, HCT116 GI₅₀ < 0.1 μM). CFI-401870 displayed low off-target activity (>500×), and microsomal stability (T(1/2) > 30 min). CFI-401870 recapitulated the phenotype of TTK RNAi, demonstrated in vivo tumor growth inhibition upon oral dosing, and was selected for preclinical evaluation.

References : Liu Y. et al.: J. Med. Chem., 58(8), 3366-3392, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.