[2349373-70-0]    

Synonyms : 4-((5-(2-Chloro-4-cyclopropylphenyl)-1,3,4-oxadiazol-2-yl)thio)butanoic acid

Applications : CCG-232964 is a highly potent new class of inhibitor of Rho/myocardin-related transcription factor (MRTF)/serum response factor (SRF)-mediated gene transcription (SRE. L IC₅₀ = 1.2 pM). CCG-232964 may be a potential antifibrotic agent for scleroderma. CCG-232964 significantly reduced bleomycin-induced dermal fibrosis.

References : Kahl J. D. et al.: J. Med. Chem., 62(9), 4350-4369, 2019.

Storage : Keep container tightly closed under nitrogen or argon and kept at -20^oC for long-term storage.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.