[1613589-09-5]    

Synonyms : (2S)-Isopropyl 2-(((((2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-fluoro-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate; AL-335

Applications : Adafosbuvir is a potent inhibitior of hepatitis C virus (HCV) NS5B polymerase with IC50 values as low as 27 nM. This is a lead compound,demonstrated high levels of the nucleoside triphosphate in vitro in primary human hepatocytes and Huh-7 cells as well as in dog liver following a single oral dose.This compound was selected for the clinical development and showed promising results in phase 1 and 2 trials.

References : Wang G. et al.: J. Med. Chem., 62(9), 4555-4570, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.