[1229018-87-4]    

Synonyms : N-(3-(4,5-Diethyl-6-oxo-1,6-dihydropyrimidin-2-yl)-4-propoxyphenyl)-2-(4-methylpiperazin-1-yl)acetamide; TPN171

Applications : TPN-171 is a potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6. TPN-171 is a clinical candidate for the treatment of pulmonary arterial hypertension. Also TPN-171 was proven to exert a longer lasting effect than Sildenafil in animal models, providing a foundation for a once-daily oral administration for its clinical use.

References : Wang Z. et al.: J. Med. Chem., 62(10), 4979-4990, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.