[136310-93-5]    

Synonyms : (1R,2R,4S,5S,7s)-7-(2-hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium bromide: BA679 BR

Applications : Tiotropium bromide is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. Tiotropium bromide is used to treat lung diseases such as asthma and chronic obstructive pulmonary disease (COPD).

References : Barnes P. J. et al.: Expert Opin Investig Drugs 10(4), 733-740, 2001; ZuWallack A. R. et al.: Expert Opin Pharmacother., 5(8), 1827-1835, 2004;
Lipson D. A. et al.: Int. J. Chron Obstruct Pulmon Dis., 1(2), 107-114, 2006;
[Mamary A. J. et al.: Expert Rev Respir Med., 3(3), 211-220, 2009; Szmidt M. Pneumonol Alergol Pol., 80(3), 255-262, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.