[473727-83-2]    

MFCD16628072

Synonyms : (R)-2-Hydroxy-N,N-dimethyl-3-((2-((1-(5-methylfuran-2-yl)propyl)amino)-3,4-dioxocyclobut-1-en-1-yl)amino)benzamide; SCH-527123; MK-7123

Applications : Navarixin is a potent, allosteric and orally active antagonist of both CXCR1 and CXCR2, with Kd values of 41 nM for cynomolgus CXCR1 and 0.20 nM, 0.20 nM, 0.08 nM for mouse, rat and cynomolgus monkey CXCR2, respectivelly. ANavarixin can be useful in the research of inflammatory diseases such as chronic obstructive pulmonary disease (COPD). Also, this has been found to exert anti-tumor activity in xenograft models of breast cancer, colorectal cancer, melanoma and spontaneous colon cancer, liver metastasis.

References : Gonsiorek W. et al.: J. Pharmacol Exp Ther., 322(2), 477-485, 2007; Chapman R. W. et al.: J. Pharmacol Exp Ther., 322(2), 486-93, 2007; Ning Y. et al.: Mol Cancer Ther., 11(6), 1353-64, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.