SynInnova Laboratories Inc.

SI-5149

PF-03715455, >98% (HPLC)

CAS No. :

[1056164-52-3]

Synonyms : 1-(3-(tert-Butyl)-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl)-3-(2-((3-(2-((2-hydroxyethyl)thio)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio)benzyl)urea

Price and Availability
Pack Size	Price in USD	Quantity	Availability	Shipping Status
5MG	Request Quote	- +	Back Order	Estimated to Ship on 12.02.2024
25MG	Request Quote	- +	Back Order	Estimated to Ship on 12.02.2024
100MG	Request Quote	- +	Back Order	Estimated to Ship on 12.02.2024
250MG	Request Quote	- +	Back Order	Estimated to Ship on 12.02.2024
500MG	Request Quote	- +	Back Order	Estimated to Ship on 12.02.2024

Note: PF-03715455 is not in stock, can be available through custom synthesis. The estimated lead-time is 4-6 weeks. The product will be characterized by NMR and MS analysis. Purity (HPLC) is usually >98%. COA, QC data, SDS will be provided along with the product. For information on pricing and availability please contact us at sales@syninnova.com or submit the following Bulk Quote Request. We respond promptly. Thank You!

Chemical Properties
Mol. Formula : C₃₅H₃₄ClN₇O₃S₂	Mol. Weight : 700.27
Appearance : Solid	Melting Point : Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : PF-03715455 is a potent inhaled p38 MAPK inhibitor. PF-03715455 shows some selectivity for p38α over p38β with respective IC50 values of 0.88 and 23 nM. PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 has potential for the treatment of chronic obstructive pulmonary disease (COPD).

References : Norman P. et al.: Expert Opin Investig Drugs 24(3), 383-392, 2015; Millan D. S. et al.: J. Med Chem., 54(22), 7797-7814, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Your request for quote will also be accepted by e-mail at sales@syninnova.com or Fax: +1 780 485 2963.

Product ID : SI-5149

Product Name : PF-03715455

Note : If you do not find your required compound in our catalogue, or not commercially available, please contact us, we will assist you to get your desired molecule. We only charge if we deliver to your satisfaction.

Site is under construction and it will coming soon. Please contact us at sales@syninnova.com for COA. Thank you!

Site is under construction and it will coming soon. Please contact us at sales@syninnova.com for HNMR. Thank you!

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SI-5149

PF-03715455, >98% (HPLC)

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