[1260832-60-7]    

Synonyms : (6-((5-Fluoro-2-((3,4,5-tris(methoxy-d₃)phenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl)methyl dihydrogen phosphate; R788-d₉

Applications : Fostamatinib-d9 is the deuterium labelled version analog of Fostamatinib, which is an oral prodrug of the active compound Tamatinib. Tamatinib is an orally available and competitive Syk/FLT3 inhibitor. Tamatinib is a potential drug for treatment of the inflammation associated with and causing bronchial asthma resulting from allergen-induced airway hyperresponsiveness (AHR).

References : Stephen P McAdoo P. S. et al.: Drugs Future 36(4), 273, 2011; Sylvia Braselmann S. et al.: J. Pharmacol Exp Ther., 319(3), 998-1008, 2006; Hoon-Suk Cha et al.: J. Pharmacol Exp Ther., 317(2), 571-578, 2006.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.