[1224844-38-5]    

MFCD22124893

Synonyms : 5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]oxazol-2-amine; MLN0128; INK-128;TAK-228

Applications : Sapanisertib is a potent and selective mTOR inhibitor with IC50 of 1 nM in cell-free assays; >200-fold less potent to class I PI3K isoforms, superior in blocking mTORC1/2 and sensitive to pro-invasion genes (vs Rapamycin). Sapanisertib is in phase II clinical trials for breast cancer, endometrial cancer, glioblastoma, renal cell carcinoma, and thyroid cancer

References : Liu A. et al.: Drug Discovery Today: Therapeutic Strategies. 6(2), 47-55, 2009; Hsieh A. C. et al.: Nature. 485(7396), 55-61, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.