[313254-51-2]    

MFCD00992334

Synonyms : 2,2-Diphenyl-N-(4-(N-(thiazol-2-yl)sulfamoyl)phenyl)acetamide

Applications : ICA-121431 is a potent, selective inhibitor of the human Nav1.3 and Nav1.1 voltage gated sodium channels (IC50 = 19 nM) with little or no activity against human Nav1.5 or Nav1.7 channels. Voltage-gated sodium channels initiate action potentials in brain neurons, and sodium channel blockers are used in therapy of epilepsy.

References : McCormack K. et al.: Proc Natl Acad Sci U S A. 110(29), E2724-32, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.