[1494581-70-2]    

Synonyms : 4-(((3r,5r,7r)-Adamantan-1-yl)methoxy)-N-(azetidin-1-ylsulfonyl)-5-cyclopropyl-2-fluorobenzamide; RG-7893

Applications : GDC-0276 is a potent, selective, reversible and orally active NaV1.7 inhibitor with an IC50 value of 0.4 nM. GDC-0276 is well tolerated and exhibits a good pharmacokinetic profile. GDC-0276 has the potential for the treatment of pain and to address shortcomings of existing pain medications, such as addiction and off-target side effects.

References : Steven J. McKerrall et al.: Bioorganic & Medicinal Chemistry Letters 28(19), 3141-3149, 2018;Takahashi R. H. et al.: Drug Metab Lett., 13(1), 37-44, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.