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SI-5488

PF-5274857 hydrochloride, >98% (HPLC)

CAS No. : 
[1613439-62-5]    
MDL No. : 
MFCD24387542
Synonyms : 1-(4-(5’-Chloro-3,5-dimethyl-[2,4'-bipyridin]-2'-yl)piperazin-1-yl)-3-(methylsulfonyl)propan-1-one hydrochloride

Price and Availability
Pack Size Price in USD Quantity Availability Shipping Status
10MG180.00 Back Order Estimated to Ship on 01.20.2025
50MG780.00 Back Order Estimated to Ship on 01.20.2025
100MG1480.00 Back Order Estimated to Ship on 01.20.2025
250MG2480.00 Back Order Estimated to Ship on 01.20.2025
Chemical Properties
C20H25ClN4O3S . HCl 473.41
Solid Not available
For Laboratory research use only, not for drug, household or other uses.
Applications : PF-5274857 hydrochloride is a potent, selective, orally active and brain-penetrant antagonist of SMO, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-5274857 hydrochloride has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.
References : Rohner A. et al.: Mol Cancer Ther., 11(1), 57-65, 2012.
Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SI-5488

Product Name : PF-5274857 hydrochloride

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