[3545-67-3]    

Synonyms : N4-(7-Chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine dihydrochloride

Applications : Chloroquine dihydrochloride is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine dihydrochloride is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine dihydrochloride is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).

References : Said A. et al.: J. Immunol., 193(12), 6135-43, 2014; Tuomela J. et al.: Oncol Lett., 6(6), 1665-1672, 2013; Mohamed F. E. et al.: Liver Int., 35(3):1063-76, 2015; Colson P. et al.: Int J. Antimicrob Agents55(4), 105932, 2020; Savarino A. et al.: J. Clin Virol., 20(3), 131-135, 2001.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.