[1164462-05-8]    

MFCD03829939

Synonyms : (E)-N-(2-(2-Methyl-1H-indol-1-yl)ethyl)-3-(3,4,5-trimethoxyphenyl)acrylamide

Applications : TG4-155 is a potent, brain-permeant and selective EP2 receptor antagonist with a Ki of 9.9 nM. TG4-155 shows low nanomolar antagonist activity against only EP2 and DP1. TG4-155 has an EP2 Schild KB of 2.4 nM and displays 550-4750-fold selectivity for EP2 over EP1, EP3, EP4 and IP, but only 14-fold selectivity against the DP1 receptor.

References : Jiang J. et al.: J Pharmacol Exp Ther., 344(2), 360-7, 2013; Ganesh T. et al.: J. Med. Chem., 57(11), 4454-65, 2014; Jiang J. et al.: Proc Natl Acad Sci U S A. 109(8), 3149-54, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.