[1029044-16-3]    

MFCD28900745

Synonyms : 5-((5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine; PLX-3397

Applications : Pexidartinib is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib induces cell apoptosis and has anticancer activity.

References : DeNardo D. G. et al.: Cancer Discov., 1(1), 54-67, 2011; Kuse Y. et al.: Mol Vis., 24, 536-545, 2018; Lee J. H. et al.: Invest New Drugs 38(1), 99-110, 2020; Merry T. L. et al.: Int. J. Obes (Lond) 44(1), 245-253, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.