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SI-5762

SNX-5422, >98% (HPLC)

CAS No. : 
[908115-27-5]    
Synonyms : (1r,4r)-4-((2-Carbamoyl-5-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenyl)amino)cyclohexyl glycinate; PF-04929113

Price and Availability
Pack Size Price in USD Quantity Availability Shipping Status
5MG250.00
-
+
Back Order Estimated to Ship on 01.19.2025
10MG450.00
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+
Back Order Estimated to Ship on 01.19.2025
25MG650.00
-
+
Back Order Estimated to Ship on 01.19.2025
50MG1250.00
-
+
Back Order Estimated to Ship on 01.19.2025
100MG2250.00
-
+
Back Order Estimated to Ship on 01.19.2025
Chemical Properties
C25H30F3N5O4 521.54
Solid Not available
For Laboratory research use only, not for drug, household or other uses.
Applications : PF-04929113 is a potent and selective Hsp90 inhibitor with Kd of 41 nM and induces Her-2 degradation with IC50 of 37 nM. PF-04929113 has been discontinued because of ocular toxicity seen in animal models and in a separate phase I study.
References : Huang K. H. et al.: J. Med Chem., 52(14), 4288-4305, 2009; Yutaka Okawa. et al.: Blood 113(4), 846-855, 2009; Lamoureux F. et al.: Clin Cancer Res., 17(8), 2301-2313, 2011.
Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SI-5762

Product Name : SNX-5422

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