[1316755-16-4]    

MFCD28502251

Synonyms : (S)-5-(Benzyloxy)-2-(2,2-diphenylacetyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; EMA401; PD-126055

Applications : Olodanrigan is a highly selective, orally active, peripherally restricted angiotensin II type 2 receptor (AT2R) antagonist. It is under development as a neuropathic pain therapeutic agent. Olodanrigan (EMA401) analgesic action appears to involve inhibition of augmented AngII/AT2R induced p38 and p42/p44 MAPK activation, and hence inhibition of DRG neuron hyperexcitability and sprouting of DRG neurons.

References : Rice A. S. et al.: Lancet., 383(9929), 1637-47, 2014; Koyama S. et al.: Scientific Reports 8, 16402, 2018; Anand U. et al.: Mol Pain.,11, 38, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.