[1020720-04-0]    

Synonyms : (Benzo[d]isoxazol-3-yl-d₄)methanesulfonamide; AD 810-d₄; CI 912-d₄

Applications : Zonisamide-d4 is the deuterium labelled version analog of Zonisamide, which is an inhibitor of zinc enzyme carbonic anhydrase (CA), with Kis of 35.2 nM and 20.6 nM for human mitochondrial isozyme hCA II and hCA V, respectively. Zonisamide has antiepileptic activity. Zonisamide can be used for the rsearch for epilepsy, seizures and Parkinson's disease.

References : Peters D. H. et al.: Drugs 45(5), 760-87, 1993; De Simone G. et al.: Bioorg Med Chem Lett., 15(9), 2315-20, 2005.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.