SynInnova Laboratories Inc.

SI-853

PF-06821497, >98% (HPLC)

CAS No. :

[1844849-11-1]

Synonyms : (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one

Price and Availability
Note: This product has been withdrawn from sale for commercial reasons.

Chemical Properties
Mol. Formula : C₂₂H₂₄Cl₂N₂O₅	Mol. Weight : 467.34
Appearance : White solid	Melting Point : Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : PF-06821497 is a novel potent, selective, orally bioavailable EZH2 inhibitor with Ki of <0.1 and 1.15 nM aginast both wt and mutant Y641N EZH2, respectively.

References : Kung P. P. et al.: J. Med. Chem., 61(3), 650-665, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SI-853

Product Name : PF-06821497

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SI-853

PF-06821497, >98% (HPLC)

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