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SI-853

PF-06821497, >98% (HPLC)

CAS No. : 
[1844849-11-1]    
Synonyms : (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one

Price and Availability
Note: This product has been withdrawn from sale for commercial reasons.
Chemical Properties
C22H24Cl2N2O5 467.34
White solid Not available
For Laboratory research use only, not for drug, household or other uses.
Applications : PF-06821497 is a novel potent, selective, orally bioavailable EZH2 inhibitor with Ki of <0.1 and 1.15 nM aginast both wt and mutant Y641N EZH2, respectively.
References : Kung P. P. et al.: J. Med. Chem., 61(3), 650-665, 2018.
Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SI-853

Product Name : PF-06821497

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