[931398-72-0]    

MFCD22580424

Synonyms : N-​[[1,​2-​Dihydro-​4-​hydroxy-​2-​oxo-​1-​(phenylmethyl)-​3-​quinolinyl]carbonyl]​glycine

Applications : It is the selective inhibitor of the hypoxia inducible factor (HIF) prolyl-hydroxylases, which is a master regulator of the cellular-response to hypoxia, are regulated by the post-translational modification of prolyl-residues in oxygen-dependent degradation domains in the HIFα subunit. HIFα prolyl-hydroxylation signals for its degradation by the proteosome.

References : Murray. J. K. et. al.: J.Comb. Chem., 12, 676, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.