[138489-18-6] of the unlabelled compound

Synonyms : 2-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-3-(1-methyl-d₃ indol-3-yl)maleimide methanesulfonate salt; RO 31-8220 Methanesulfonate-d₃; RO 31-8220 Mesylate-d₃

Applications : It is a deuterium labelled version of RO 31-8220 Mesylate, which is a protein kinase C inhibitor, with activity at other protein kinases (IC₅₀ values are 33, 3, 8, 15 and 38 nM for PKCα, MAPKAP-K1b, MSK1, GSK3β and S6K1 respectively). Activates JNK and glycogen synthase, and inhibits MAPK and ERK2, in rat adipocytes and L6 myotubes. Also inhibits voltage-dependent Na+ channels in the micromolar range.

References : Davies. S.P. et. al.: Biochem. J. 351, 95, 2000; PMID: 10998351; Lingameneni et. al.: FEBS Lett. 473, 265, 2000; PMID: 10812087; Standaert. M. L. et. al.: Endocrinology 150, 2145, 1999; Mou. H. et. al .: Cell Stem Cell 19, 217, 2016; PMID: 27320041.

Storage : Keep container tightly closed under nitrogen or argon and store at -20^oC for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.