[66695-14-5]    

MFCD00674902

Synonyms : 7-Hydroxy-2H-1-benzopyran-2-one glucuronide sodium salt; Umbelliferone glucuronide sodium salt

Applications : Coumarin is a natural compound has therapeutic usefulness in the treatment of lymphedema and different types of cancer. Several previous pharmacokinetic studies of coumarin have been performed in humans, which revealed extensive first-pass metabolism of the compound. 7-Hydroxycoumarin (7-HC) and its glucuronide (7-HC-G) are the main metabolites formed in humans, and via this route, 80 to 90% of the absorbed coumarin is excreted into urine, mainly as 7-HC-G.

References : Hanneke G M Wittgen et. al.: Drug Metabolism and Disposition, 40(6), 1076, 2012.

Storage : Keep container tightly closed under nitrogen or argon and kept at -20^oC for long-term storage.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.