[14622-47-0]    

Synonyms : 9,11α-Epoxy-17,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 9,11-Epoxy-9H-cyclopenta[a]phenanthrene pregna-1,4-diene-3,20-dione ; (11α,16α)-9,11-Epoxy-17,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione

Applications : This is an impurity of Dexamethasone (Dexamethasone EP impurity I), which is a type of corticosteroid medication. It is used in the treatment of many conditions, including rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic obstructive lung disease, croup, brain swelling, and along with antibiotics in tuberculosis.

References : LaLone C. A. et al.: Environ Toxicol Chem. 31 (3), 611-622, 2012; Adcock I. M. et al.: Br. J. Pharmacol. 127 (4), 1003-1011, 1999; Rocksén D. et al. Clin Exp Immunol. 122 (2), 249-256, 2000; Roussel D. et al., FEBS Lett., 541(1-3), 75-79, 2003; Maher H.M. et al., J. Pharm Biomed Anal.,124, 216-227, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.