[442632-72-6]    

MFCD03036245

Synonyms : N-​[2-​(2-​Methyl-​1H-​indol-​3-​yl)​ethyl]​-​2-​thiophenecarboxamide

Applications : CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. Both classes of compounds inhibit formation of actin filament comet tails by listeria and podosomes by monocytes.

References : Nolen B.J. et. al.: Nature, 460 (7258), 1031, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term storage.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.