[404844-02-6]    

Synonyms : N-(4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)-4-(piperazin-1-ylmethyl)benzamide; Imatinib EP impurity C; N-Desmethyl gleevec; CGP-74588; Norimatinib; STI 509-00

Applications : N-Desmethyl imatinib (Imatinib EP impurity C) is a metabolite of Gleevec, which is a tyrosine kinases inhibitor for the treatment of cancer.

References : Heinrich M. C.: et al. Blood. 96 (3), 925-932, 2000; Guida T. et al.: Clin Cancer Res.13 (11), 3363-3369, 2007; Okuda K. et al.: Blood. 97 (8), 2440-2448, 2001; Yao J. C. et al.: Clin Cancer Res. 13 (1), 234-240, 2007; Sun X. C. et al.: World J. Gastroenterol. 19 (15), 2340-2347, 2013; Yildiz C. et al. Eur J. Obstet Gynecol Reprod Biol. 197, 159-163, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.