MFCD28386062

[183322-45-4] of the unlabelled compound

Synonyms : 4-​[(3-​Bromophenyl)​amino]​-​6,7-​dimethoxy-d₆-quinazoline hydrochloride

Applications : Labelled analogue of PD153035, has been found to inhibit EGF-dependent EGFR phosphorylation in a variety of human cancer cell lines over-expressing EGFRs, which include A431, Difi, DU145, MDA-MB-468, ME180 and C4i, with IC50 of 0.22 μM, 0.3 μM, 0.4 μM, 0.68 μM, 0.95 μM and 2.5 μM respectively leading to suppression of proliferation and clonogenicity in those cell lines.

References : Mendelsohn B M.et. al.: Clin Cancer Res., 3(11), 2099,1997.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term storage.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.