[286370-15-8]    

MFCD14155620

Synonyms : N-​[2-​Chloro-​4-​[(6,​7-​dimethoxy-​4-​quinazolinyl)oxy]phenyl]-​N'-​propyl-​urea

Applications : Quinazoline urea derivative KRN 633 is a selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase that suppresses tumor angiogenesis and growth. KRN633 was well tolerated and had no significant effects on body weight or the general health of the animals and useful in the treatment of solid tumors and other diseases that depend on pathologic angiogenesis.

References : Nakamura K. et. al.: Molecular Cancer Therapeutics, 3(12),1639, 2004.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term storage.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.