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MFCD00017259

Synonyms : (6E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide

Applications : Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is the principal pungent component in hot peppers, including red chilli peppers, and it has a profound antiproliferative effect on prostate cancer cells, inducing the apoptosis of both androgen receptor (AR)-positive (LNCaP) and -negative (PC-3, DU-145) prostate cancer cell lines associated with an increase of p53, p21, and Bax.Capsaicin inhibited NF-kappa activation by preventing its nuclear migration.

References : Mori A.et.al.: Cancer Res., 66(6), 3222, 2006.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term storage.

Caution : Highly Irritant and Lachrymator! In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.