[1189713-08-3]    

Synonyms : 1-(Methyl-d₃)-7-methyl-1H-purine-2,6,8(3H,7H,9H)-trione

Applications : 1,7-Dimethyluric acid (1-methyl-d3) is a deuterium labelled matabolite of Caffeine, which is a central nervous system stimulant of the methylxanthine class. It is the world's most widely consumed psychoactive drug. Antagonist at A1 and A2A adenosine receptors and inhibitor of cyclic nucleotide phosphodiesterases. Mobilizes calcium from intracellular stores and inhibits benzodiazepine binding to GABA receptors.

References : Nehlig A. et al.: Brain Res Rev.,17(2), 139-170, 1992; Fisone G. et al.:Cell Mol Life Sci., 61(7-8), 857-872, 2004; Chen X. et al.: J.Neuroinflammation 5, 12. 2008.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.