[1257-19-8]    

Synonyms : 1,4-Bis[(2,3,4-trimethoxyphenyl)methyl]piperazine; 1,4-Bis(2,3,4-trimethoxybenzyl)piperazine; Trimetazidine EP impurity B

Applications : This is an impurity of Trimetazidine (Trimetazidine EP impurity B), which is an anti-ischemic (anti-anginal) metabolic agent, which improves myocardial glucose utilization through inhibition of long-chain 3-ketoacyl CoA thiolase activity and results in a reduction in fatty acid oxidation and a stimulation of glucose oxidation.

References : Kantor P. F. et al.: Circ Res. 86(5), 580-588, 2000; Liu Z. et al.: Metabolism. 65(3), 122-130, 2016; Yang Q. et al.: Int. J. Clin Exp Pathol. 8(4), 3735-3741, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.