[108736-10-3]    

Synonyms : (S)-2-((3S,5aS,8aS,9aS)-3-Methyl-1,4-dioxodecahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-4-phenylbutanoic acid; Ramiprilat diketopiperazine

Applications : This is an impurity of Ramipril (Ramipril EP impurity K), which is an angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure, heart failure, and diabetic kidney disease. Also used to prevent cardiovascular disease in those at high risk.

References : Stevens B. R. et al.: Comp Biochem Physiol C, 91(2), 493-497, 1988; Kohlstedt K. et al.: Circ Res, 94(1), 60-67, 2004; Ceconi C. et al.: Cardiovasc Drugs Ther, 21(6), 423-429, 2007; Raasch W. et al.: J. Hypertens, 22(3), 611-618, 2004; Cushman D. W. et al.: Br. J. Clin Pharmacol, 28, 115S-131S, 1989; Toffoli B. et al.: Mol Cell Endocrinol, 331(1), 136-142, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.