[73858-59-0]    

Synonyms : Alendronic acid impurity 2

Applications : 2-Pyrrolidinylphosphonic acid is an impurity of Alendronate, which is a nitrogen-containing, second generation bisphosphonate used for osteoporosis, osteogenesis imperfecta, and several other bone diseases.

References : Fisher J. E. et al.: Proc Natl Acad Sci U S A, 96(1), 133-138, 1999; Bergstrom J. D. et al. Arch Biochem Biophys, 373(1), 231-241, 2000; Keller R. K. et al.: Biochem Biophys Res Commun, 266(2), 560-563, 1999;
Elliott S. N. et al.: Life Sci, 62(1), 77-91, 1998; Stearns M. E. et al.: Invasion Metastasis, 16(3), 116-131, 1996.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.