[1020719-55-4]    

Synonyms : (9)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl-d₄]-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one; 9-Hydroxy risperidone-d₄; Paliperidone-d₄

Applications : This is a deuterium labelled impurity or the main active metabolite of Risperidone (Risperidone-d4 EP impurity C), also known as Paliperidone. It is a potent serotonin-2A and dopamine-2 receptor antagonist, used in the treatment of schizophrenia.

References : Zhu H. J. et al.: Neuropsychopharmacology, 32(4), 757-764, 2007; Yang M. C. et al.: Psychopharmacology (Berl), 217(3), 397-410, 2011; Gass P. et al.: Prog Neuropsychopharmacol Biol Psychiatry, 36(1), 71-77, 2012; Roenker N. L. et al.: Neurosci Lett, 500(3), 167-171, 2011; Dremencov E. et al.: Psychopharmacology (Berl), 194(1), 63-72, 2007; Schwartzer J. J. et al.: Psychopharmacology (Berl), 203(4), 653-63, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.