[15775-74-3]    

Synonyms : Pregn-4-ene-3,20-dione-d₉

Applications : Progesterone-d9 is a deuterium labelled version of Progesterone, which is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. A potent agonist of the nuclear progesterone receptor (nPR) with Kd of 1 nM; An agonist of the membrane progesterone receptors(mPRs); An antagonist of the σ1 receptor.

References : Owen G. I. et al.: J. Biol Chem, 273(17), 10696-10701, 1998; Joshi P. A. et al.: Nature, 465(7299), 803-807, 2010; Bitran D. et al.: Pharmacol Biochem Behav, 45(2), 423-428, 1993; Carroll J. C. et al.: J. Neurosci, 27(48), 13357-13365, 2007; Roof R. L. et al.: Exp Neurol, 129(1), 64-69, 1994.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.