[123853-39-4]    

Synonyms : 4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid; Clevidipine butyrate impurity A

Applications : This is an impurity of Felodipine, which is a long-acting 1,4-dihydropyridine calcium channel blocker, used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.

References : Johnson J. D. et al.: J. Pharmacol Exp Ther, 226(2), 330-334, 1983; Rodler S. et al.: J. Mol Cell Cardiol, 27(10), 2295-2302, 1995; Yiu S. et al.: J. Med Chem, 39(23), 4576-4582, 1996; Ding Y. et al.: Hypertension, 32(4), 718-723, 1998; Yang Z. et al.: Cardiovasc Res, 53(1), 227-231, 2002; Perez-Reyes E. et al. J. Pharmacol Exp Ther, 328(2), 621-627, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.