[740816-86-8]    

Synonyms : O-Desmethyl PKC412; CGP 62221

Applications : O-Desmethyl midostaurin is an active metabolite of Midostaurin via cytochrome P450 liver enzyme metabolism. O-Desmethyl midostaurin can be used as an indicator for Midostaurin metabolism in vivo. Midostaurin is a multi-targeted protein kinase inhibitor, used for the treatment of acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) and advanced systemic mastocytosis.

References : Fabbro D. et al.: Pharmacol Ther., 82(2-3), 293-301, 1999; Ikegami Y. et al.: Jpn. J. Pharmacol., 70(1), 65-72, 1996; Manley P. W. et al.: Biochemistry 57(38) 5576-5590, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.