[137132-70-8]    

Synonyms : 8,11-Dihydroxy-4-(2-hydroxyethyl)-6-((2-((2-hydroxyethyl)amino)ethyl)amino)-1,2,3,4-tetrahydronaphtho[2,3-f]quinoxaline-7,12-dione

Applications : This is an impurity of Mitoxantrone (Mitoxantrone EP impurity D), which is a topoisomerase II inhibitor; also inhibits protein kinase C (PKC). Mitoxantrone is an antitumor antibiotic drug. Also, this is a COVID-19 related research chemical.

References : Seitz M. Curr Opin Rheumatol, 11(3), 226-232, 1999; Hirata S. et al.: Arthritis Rheum, 32(9), 1065-1073, 1989; Segal R. et al.: Semin Arthritis Rheum, 20(3), 190-200, 1990; Hirata S. et al.: Arthritis Rheum, 32(9), 1065-1073, 1989; Genestier L. et al.: J. Clin Invest, 102(2), 322-328, 1998; Cronstein B. N. et al.: J. Clin Invest, 92(6), 2675-2682, 1993.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.