[25018-67-1]    

MFCD00067639

Synonyms : 1,2:4,5-Bis-O-(1-Methylethylidene)-β-D-fructopyranose; Topiramate impurity D

Applications : This is an impurity of Topiramate, which is a mutil-targeted inhibitor, including voltage-gated sodium channel and calcium channel, AMPA/kainate receptor and carbonic anhydrase, used to treat epilepsy.

References : Taverna S. et al.: J. Pharmacol Exp Ther., 288(3), 960-968, 1999; Gryder D. S. et al.: J. Neurosci., 23(18), 7069-7074, 2003; Yang Y. et al.: Brain Res., 804(2), 169-176, 1998; Kaminski R. M. et al.: Neuropharmacology, 46(8), 1097-1104, 2004; Koh S. et al.: Ann Neurol., 50(3), 366-372, 2001; Nakamura J. et al. Eur J Pharmacol., 254(1-2), 83-89, 1994.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.