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SL-678

O6-(3-fluorobenzyl)guanine, 98%

CAS No. : 
[168098-94-0]    
MDL No. : 
MFCD30146121
Synonyms : 6-(3-Fluorobenzyloxy)-9H-purin-2-ylamine

Price and Availability
Pack Size Price in USD Quantity Availability Shipping Status
25MG980.00 Back Order Estimated to Ship on 11.25.2024
100MG2980.00 Back Order Estimated to Ship on 11.25.2024
Chemical Properties
C12H10FN5O 259.24
Solid Not available
For Laboratory research use only, not for drug, household or other uses.
Applications : O6-Alkylguanine derivatives sensitize tumor cells to chloroethylnitrosourea (CENU) chemotherapy by inactivation of O6-methylguanine-DNA methyltransferase (MGMT), which repairs CENU-induced O6-alkylguanines in DNA. The O6-Fluorobenzylguanines with a fluoro-substitution at the 4-or 3-position of the benzyl group were comparable to O6-benzylguanine and were powerful MGMT inactivators.
References : Katsuyoshi. M. et. al.: .Life Sciences, 58(19), 303,  1996.
Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SL-678

Product Name : O6-(3-fluorobenzyl)guanine

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