[1797883-74-9]    

Synonyms : 2-(2-Fluoro-[1,1'-biphenyl]-4-yl)-2,3-dimethylsuccinic acid

Applications : This is an impurity of Flurbiprofen (Flurbiprofen EP impurity B). A potent, orally active nonsteroidal anti-inflammatory drug (NSAID) with antipyretic and analgesic activities. Flurbiprofen is commonly used for the research of inflammatory diseases, including osteoarthritis and rheumatoid arthritis. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor, can be used for the research of colorectal cancer.

References : Xiaobo W. et al.: Oncol Lett., 20(5), 132, 2020; King J. G. Jr. et al.: Oncogene 20(47), 6864-6870, 2001; Mishra V. et al.: Neuropharmacology 59(7-8), 582-588, 2010; Sun B. et al.: Biochem Biophys Res Commun., 409(4), 808-813, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.