MFCD30146154

[149647-78-9] of the unlabelled compound

Synonyms : Suberanilohydroxamic acid-¹³C₆

Applications : 13C- Labelled compound of Suberoylanilide hydroxamic acid (SAHA) is a potent inhibitor of HDAC activity and has undergone initial evaluation in several Phase I and II clinical trials. HDACs are enzymes that catalyse the removal of the acetyl moiety from the lysine residues of proteins, including the core nucleosomal histones. Cell culture studies demonstrating that vorinostat enhances the antitumour efficacy of radiation therapy or chemotherapy.It can be used as analytical reference standard.

References : Richon. V. M.: Br. J. Cancer, 95(S1), S2, 2006.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.