[249503-25-1]    

MFCD28385877

Synonyms : (2S,3S,4R,5R)-2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol; BCX4430; Immucillin-A

Applications : Galidesivir is an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. This is an approved drug in clinical trials for COVID-19.

References : Taylor R. et al.: J. Infect Public Health 9(3), 220-226, 2016; Elfiky A. A. et al.: Life Sci. 117592, Mar 25 2020; Warren T. K. et al. Nature. 2014, 508(7496), 402-405, 2014; Julander J. G. et al. Antimicrob Agents Chemother., 58(11), 6607-6614, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.