[171009-07-7]    

MFCD00710300

Synonyms : 4-(4-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylbenzene-1,3-diol

Applications : CCT018159 is a novel inhibitor of heat shock protein 90 (Hsp90) ATPase activity (IC50 = 5.7 μM) that displays selectivity over human Hsp72 and topoisomerase II. Inhibits proliferation of HCT116 human colon tumor cells and produces upregulation of Hsp70 and downregulation of c-Raf and cdk4. More soluble than 17-AAG and is independent of NQO1/DT-diaphorase and P-glycoprotein expression.

References : Kwai-Ming J. Cheung et al.: Bioorg.Med.Chem.Lett. 15(14), 3338-43, 2005; Dymock W. B. et al.: J. Med. Chem., 48(13), 4212-5, 2005; Sharp Y. S. et al.: Cancer Res., 67(5), 2206-16, 2007.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.