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SI-5836

PLX 4720-d7, >98% (HPLC)

Isotopic Purity : 
98 atom % D
CAS No. : 
[1304096-50-1]    
Synonyms : N-(4-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-3,5-difluorophenyl)propane-1-sulfonamide-d7

Price and Availability
Pack Size Price in USD Quantity Availability Shipping Status
5MG650.00
-
+
Back Order Estimated to Ship on 01.18.2025
10MG1150.00
-
+
Back Order Estimated to Ship on 01.18.2025
Chemical Properties
C23H11D7ClF2N3O3S 496.96
Solid Not available
For Laboratory research use only, not for drug, household or other uses.
Applications : PLX4720-d7 is the deuterium labelled version analog of PLX4720, which is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), 10-fold selectivity for B-RafV600E than wild-type B-Raf.
References : Tsai J. et al.: Proc Natl Acad Sci U S A, 105(8), 3041-3046, 2008; Paraiso K. H. et al.: Cancer Res., 71(7), 2750-2760, 2011; Nucera C. et al.: Proc Natl Acad Sci U S A 107(23), 10649-10654, 2010.
Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SI-5836

Product Name : PLX 4720-d7

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