[839712-25-3]    

Synonyms : 1-((1r,4r)-4-(2-(4-(2,3-Dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)urea

Applications : Didesmethyl cariprazine is a metabolite of Cariprazine and acts as the predominant circulating active moiety. Didesmethyl cariprazine has a long half-life of 1-3 weeks. Cariprazine is a antipsychotic drug candidate that exhibits high affinity for the D3 and D2 receptors, and moderate affinity for the 5-HT1A receptor.

References : Seneca N. et al.: Psychopharmacology (Berl). 218 (3), 579, 2011; Kiss B. et al. J Pharmacol Exp Ther. 333 (1), 328-340, 2010; Zimnisky R. et al.: Psychopharmacology (Berl). 226 (1), 91-100, 2013; Gao Y. et al.: Pharmacol Res Perspect., 3(1), e00073, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.