[309913-83-5]    

MFCD11973651

Synonyms : 2-(6-Chloro-5-((2S,5R)-4-(4-fluorobenzyl)-2,5-dimethylpiperazine-1-carbonyl)-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide; SCIO-469

Applications : Talmapimod is an orally active, selective, and ATP-competitive p38α inhibitor with an IC50 of 9 nM. Talmapimod shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs. Talmapimod has potential for immunomodulating, anti-inflammatory, and antineoplastic activities.

References : Hideshima T. et al.: Oncogene 23(54), 8766-8776, 2004; Navas T. et al.: Leuk Lymphoma 49(10), 1963-1975, 2008; Vanderkerken K. et al.: Cancer Res., 67(10), 4572-4577, 2007; Medicherla S. et al.: Anticancer Res., 28(6A), 3827-3833, 2008.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.