SynInnova Laboratories Inc.

SI-5153

Talmapimod hydrochloride, >98% (HPLC)

CAS No. :

[309915-12-6]

Synonyms : 2-(6-Chloro-5-((2S,5R)-4-(4-fluorobenzyl)-2,5-dimethylpiperazine-1-carbonyl)-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide hydrochloride; SCIO-469 hydrochloride

Price and Availability
Pack Size	Price in USD	Quantity	Availability	Shipping Status
5MG	Request Quote	- +	Back Order	Estimated to Ship on 12.20.2024
25MG	Request Quote	- +	Back Order	Estimated to Ship on 12.20.2024
100MG	Request Quote	- +	Back Order	Estimated to Ship on 12.20.2024
250MG	Request Quote	- +	Back Order	Estimated to Ship on 12.20.2024
500MG	Request Quote	- +	Back Order	Estimated to Ship on 12.20.2024

Note: Talmapimod hydrochloride is not in stock, can be available through custom synthesis. The estimated lead-time is 4-6 weeks. The product will be characterized by NMR and MS analysis. Purity (HPLC) is usually >98%. COA, QC data, SDS will be provided along with the product. For information on pricing and availability please contact us at sales@syninnova.com or submit the following Bulk Quote Request. We respond promptly. Thank You!

Chemical Properties
Mol. Formula : C₂₇H₃₀ClFN₄O₃ . HCl	Mol. Weight : 549.47
Appearance : Solid	Melting Point : Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Talmapimod hydrochloride is an orally active, selective, and ATP-competitive p38α inhibitor with an IC50 of 9 nM. Talmapimod hydrochloride shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs. It has potential for immunomodulating, anti-inflammatory, and antineoplastic activities.

References : Hideshima T. et al.: Oncogene 23(54), 8766-8776, 2004; Navas T. et al.: Leuk Lymphoma 49(10), 1963-1975, 2008; Vanderkerken K. et al.: Cancer Res., 67(10), 4572-4577, 2007; Medicherla S. et al.: Anticancer Res., 28(6A), 3827-3833, 2008.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Your request for quote will also be accepted by e-mail at sales@syninnova.com or Fax: +1 780 485 2963.

Product ID : SI-5153

Product Name : Talmapimod hydrochloride

Note : If you do not find your required compound in our catalogue, or not commercially available, please contact us, we will assist you to get your desired molecule. We only charge if we deliver to your satisfaction.

Site is under construction and it will coming soon. Please contact us at sales@syninnova.com for COA. Thank you!

Site is under construction and it will coming soon. Please contact us at sales@syninnova.com for HNMR. Thank you!

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SI-5153

Talmapimod hydrochloride, >98% (HPLC)

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