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SI-5153

Talmapimod hydrochloride, >98% (HPLC)

CAS No. : 
[309915-12-6]    
Synonyms : 2-(6-Chloro-5-((2S,5R)-4-(4-fluorobenzyl)-2,5-dimethylpiperazine-1-carbonyl)-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide hydrochloride; SCIO-469 hydrochloride

Price and Availability
Pack Size Price in USD Quantity Availability Shipping Status
5MGRequest QuoteBack Order Estimated to Ship on 01.22.2025
25MGRequest QuoteBack Order Estimated to Ship on 01.22.2025
100MGRequest QuoteBack Order Estimated to Ship on 01.22.2025
250MGRequest QuoteBack Order Estimated to Ship on 01.22.2025
500MGRequest QuoteBack Order Estimated to Ship on 01.22.2025

Talmapimod hydrochloride is not in stock, can be available through custom synthesis. The estimated lead-time is 4-6 weeks. The product will be characterized by NMR and MS analysis. Purity (HPLC) is usually >98%. COA, QC data, SDS will be provided along with the product. For information on pricing and availability please contact us at sales@syninnova.com or submit the following Bulk Quote Request. We respond promptly. Thank You!

Chemical Properties
C27H30ClFN4O3 . HCl 549.47
Solid Not available
For Laboratory research use only, not for drug, household or other uses.
Applications : Talmapimod hydrochloride is an orally active, selective, and ATP-competitive p38α inhibitor with an IC50 of 9 nM. Talmapimod hydrochloride shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs. It has potential for immunomodulating, anti-inflammatory, and antineoplastic activities.
References : Hideshima T. et al.: Oncogene 23(54), 8766-8776, 2004; Navas T. et al.: Leuk Lymphoma 49(10), 1963-1975, 2008; Vanderkerken K. et al.: Cancer Res., 67(10), 4572-4577, 2007; Medicherla S. et al.: Anticancer Res., 28(6A), 3827-3833, 2008.
Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SI-5153

Product Name : Talmapimod hydrochloride

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Site is under construction and it will coming soon. Please contact us at sales@syninnova.com for COA. Thank you!

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